Author: Zech

Kariko, K. et al. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol. Ther. 16, 1833–1840 (2008).Article  CAS  PubMed  Google Scholar  Kormann, M. S. et al. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nat. Biotechnol. 29, 154–157 (2011).Article  CAS  PubMed  Google Scholar  Anderson, B. R. et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 38, 5884–5892 (2010).Article  CAS  PubMed  PubMed Central  Google Scholar  Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA recognition by toll-like receptors: the…

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The Department of Homeland Security’s Science and Technology Directorate announced on Monday that it has offered contracts to six technology companies to develop digital wallet services as part of the department’s goal to advance digital technologies used in the areas of immigration and travel. According to a DHS press release, three U.S.-based companies received the awards: Credence ID, Hushmesh and SpruceID, along with European companies Ubiqu, Procivis and Netis doo. The awards were given in response to a call for proposals posted by the department last year. Each company received just under $200,000 in prize money, but could ultimately win…

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A group of entrepreneurs and executives from around the world recently completed a fellowship working to bridge the gap between the humanities and technology. The inaugural class of Virginia Tech’s Technology Leadership Institute, created and led by founder and tech executive Rishi Jaitley, aims to make art, history, religion, philosophy and other disciplines more accessible to more people in the tech industry. The two-semester program for mid-career professionals began in fall 2023 and wrapped up in April. “I think a world where the humanities are more accessible and available is a more curious and more compassionate world,” said Jaitley, who…

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Hanwha Life President Kim Dong-won (Photo courtesy of Hanwha) In January, Hanwha Life President Kim Dong-won attended the Davos Forum, interacting with global financial leaders and participating in global management discussions. During the forum, Kim discussed the Indonesian insurance market outlook and detailed cooperation plans with CEO John Riady, demonstrating Hanwha Life’s commitment to expanding its international footprint. In February, Hanwha Life signed a memorandum of understanding with Da Nang National University and the Green Umbrella Children’s Foundation to nurture Vietnam’s future financial and ICT talent. The initiative aims to unearth and develop local talent, further strengthening Hanwha Life’s…

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Europol’s head is asking lawmakers for help in weakening privacy-enhancing technologies (PETs), which he says hinder criminal investigations, and this time he’s not targeting end-to-end encryption. Well, not exactly. Europol today released a position statement highlighting its concerns about SMS Home Routing, a technology that allows telecommunications operators to continue providing services to customers when they visit another country. Most modern mobile phone users connect to networks that have roaming agreements in other countries: for example, an EE customer in the UK connects to Telefónica or Xfera when they arrive in Spain, or to T-Mobile in Croatia. This typically provides…

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KUALA LUMPUR (July 5): RHB Investment Bank (RHB IB) maintained its ‘overweight’ outlook on the property, construction, technology, healthcare, transportation, oil and gas (O&G), utilities and rubber products sectors.Meanwhile, the research firm’s target for FBM KLCI at end-2024 is 1,720 points, based on a target price-earnings (PE) ratio of 16 times financial year 2025 (FY2025) earnings per share (EPS) (a premium to the average of 15.3 times).RHB IB advised investors to “buy on the weakness” in a note on Friday, adding that the current “hesitant” sentiment provides an opportunity to accumulate stocks with solid fundamentals.Nonetheless, RHB IB’s equity outlook remains…

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Welcome to the European Centre for Democracy and Technology’s Technology Policy Brief. In this issue, we look at the most pressing technology and internet policy issues being debated in Europe, the US and internationally, and provide CDT’s perspective on the implications for digital rights. To sign up for CDT Europe’s AI newsletter, please visit our website. Please feel free to contact our team in Brussels (Silvia Lorenzo Perez, Laura Lazaro Cabrera, Aimée Duprat-Macabies, David Klotsonis): CDT Europe Appoints Digital Rights Leader Asha Allen as Director and Executive Director Photo by Asha Allen, Executive Director of CDT Europe. We are pleased…

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Ubisoft has partnered with Double Jump.Tokyo to “accelerate” the global adoption of its Web3 games, using a brand new platform called Champions Tactics: Grimoria Chronicles to offer a series of NFTs to gamers around the world. However, this is not Ubisoft’s first foray into the world of blockchain-based NFTs: the company unveiled a full-fledged NFT-based platform, Quartz, in late 2021, which quickly fizzled. Since then, Ubisoft has partnered with Immutable to try again to make something valuable out of NFTs, but nothing concrete has come from that relationship yet, so Ubisoft is hoping its third attempt will be its best…

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The Web3 Foundation has awarded a Decentralized Futures Grant to Dot Play to boost Polkadot’s gaming division.According to a statement on July 3, Dot Play is tasked with building a comprehensive platform for game developers using Polkadot’s advanced technology. The project will focus on fast-growing gaming genres by building essential integration tools and providing sustainable business support within the Polkadot ecosystem.Dot Play will provide a gaming portal to onboard new developers and support a variety of initiatives, including sponsorship of the Indy 500 Polkadot car.Additionally, Dot Play will provide technical integration to guide projects by evaluating Game Design Documents (GDDs),…

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Navin, N. E. The first five years of single-cell cancer genomics and beyond. Genome Res. 25, 1499–1507 (2015).Article  CAS  PubMed  PubMed Central  Google Scholar  Schmitt, M. W. et al. Single-molecule sequencing reveals patterns of pre-existing drug resistance that suggest treatment strategies in Philadelphia-positive leukemias. Clin. Cancer Res. 24, 5321–5334 (2018).Article  CAS  PubMed  PubMed Central  Google Scholar  Frankell, A. M. et al. The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature 616, 525–533 (2023).Article  CAS  PubMed  PubMed Central  Google Scholar  Martínez-Ruiz, C. et al. Genomic–transcriptomic evolution in lung cancer and metastasis. Nature 616, 543–552 (2023).Article  PubMed  PubMed…

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